Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function.

  title={Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function.},
  author={Yimin A. Wu and Konstadinos Moissoglu and Hong Wang and Xuejiao Wang and Henry F. Frierson and Martin A Schwartz and Dan Theodorescu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 14},
RhoGDI2 is a suppressor of metastasis in human bladder cancer. Although diminished RhoGDI2 expression in tumors is associated with decreased patient survival, normal expression in some metastatic tumors led us to wonder whether other mechanisms regulate RhoGDI2 function. Protein interaction analysis identified Src as a novel RhoGDI2 interaction partner. Gene expression profiling and immunohistochemistry of human tumors revealed that Src levels diminish as a function of bladder cancer stage. In… CONTINUE READING
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