Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells.

@article{Filosto2013SrcMC,
  title={Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells.},
  author={Simone Filosto and David S Baston and Samuel C K Chung and Cathleen R. Becker and Tzipora Goldkorn},
  journal={Molecular cancer therapeutics},
  year={2013},
  volume={12 8},
  pages={1579-90}
}
The EGF receptor (EGFR) is a proto-oncogene commonly dysregulated in several cancers including non-small cell lung carcinoma (NSCLC) and, thus, is targeted for treatment using tyrosine kinase inhibitors (TKI) such as erlotinib. However, despite the efficacy observed in patients with NSCLC harboring oncogenic variants of the EGFR, general ineffectiveness of TKIs in patients with NSCLC who are current and former smokers necessitates identification of novel mechanisms to overcome this phenomenon… CONTINUE READING
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