Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

@article{Eliceiri2002SrcmediatedCO,
  title={Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling},
  author={Brian P. Eliceiri and Xose S. Puente and John D. Hood and Dwayne G. Stupack and David D. Schlaepfer and Xiaozhu Huang and Dean Sheppard and David A. Cheresh},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={157},
  pages={149 - 160}
}
Vascular endothelial growth factor (VEGF) promotes vascular permeability (VP) and neovascularization, and is required for development. We find that VEGF-stimulated Src activity in chick embryo blood vessels induces the coupling of focal adhesion kinase (FAK) to integrin alpha(v)beta5, a critical event in VEGF-mediated signaling and biological responsiveness. In contrast, FAK is constitutively associated with beta1 and beta3 integrins in the presence or absence of growth factors. In cultured… CONTINUE READING

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