Src kinases in G-CSF receptor signaling.

  title={Src kinases in G-CSF receptor signaling.},
  author={Matthew G. Sampson and Quan-sheng Zhu and Seth J Corey},
  journal={Frontiers in bioscience : a journal and virtual library},
The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal. At least two cytosolic PTKs are primarily involved: Jak2, a member of the Janus family, and Lyn, a member of the Src family. Through poorly understood mechanisms, these kinases functionally interact with the G-CSF receptor. Jak2 primarily enlists members… CONTINUE READING