Src kinases as therapeutic targets for cancer

@article{Kim2009SrcKA,
  title={Src kinases as therapeutic targets for cancer},
  author={Lori C. Kim and Lanxi J Song and Eric B. Haura},
  journal={Nature Reviews Clinical Oncology},
  year={2009},
  volume={6},
  pages={587-595}
}
Src family kinases (SFKs) have a critical role in cell adhesion, invasion, proliferation, survival, and angiogenesis during tumor development. SFKs comprise nine family members that share similar structure and function. Overexpression or high activation of SFKs occurs frequently in tumor tissues and they are central mediators in multiple signaling pathways that are important in oncogenesis. SFKs can interact with tyrosine kinase receptors, such as EGFR and the VEGF receptor. SFKs can affect… CONTINUE READING
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