Src kinases as therapeutic targets for cancer

  title={Src kinases as therapeutic targets for cancer},
  author={Lori C. Kim and Lanxi J Song and Eric B. Haura},
  journal={Nature Reviews Clinical Oncology},
Src family kinases (SFKs) have a critical role in cell adhesion, invasion, proliferation, survival, and angiogenesis during tumor development. SFKs comprise nine family members that share similar structure and function. Overexpression or high activation of SFKs occurs frequently in tumor tissues and they are central mediators in multiple signaling pathways that are important in oncogenesis. SFKs can interact with tyrosine kinase receptors, such as EGFR and the VEGF receptor. SFKs can affect… CONTINUE READING
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SU6656, a selective src family kinase inhibitor, used to probe growth factor REVIEwS nrclinonc_129_OCT09.indd

  • Blake, A R.
  • signaling. Mol. Cell Biol
  • 2009

A phase II study [abstract

  • Yu, E. Y. et al. Dasatinib in patients with hormone-refra cancer
  • ASCO Meeting Abstracts 26, a5156
  • 2008

A quantitative analysis of kinase inhibitor selectivity

  • Karaman, M. w
  • Nat. Biotechnol
  • 2008

Identification of predictive markers of response in colorectal cancer following treatment with dasatinib, an orally active tyrosine kinase inhibitor of ABL and SRC

  • wainberg, A Z.
  • ASCO Meeting Abstracts 26,
  • 2008

Phase I trial of cetuximab (C) and dasatinib (D) in patients (pts) with advanced solid malignancies [abstract

  • Esteve, R F.
  • ASCO Meeting Abstracts
  • 2008

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