Src kinase signaling mediates estrous behavior induced by 5β-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats

@article{LimaHernndez2012SrcKS,
  title={Src kinase signaling mediates estrous behavior induced by 5$\beta$-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats},
  author={Francisco Javier Lima-Hern{\'a}ndez and Carlos Beyer and Porfirio G{\'o}mora-Arrati and Marcos Garc{\'i}a-Ju{\'a}rez and Jos{\'e} L. Encarnaci{\'o}n-S{\'a}nchez and Anne M. Etgen and Oscar Gonz{\'a}lez‐Flores},
  journal={Hormones and Behavior},
  year={2012},
  volume={62},
  pages={579-584}
}
Sexual receptivity facilitated by unesterified estradiol: Dependence on estrogen and progestin receptors and priming dose of estradiol benzoate.
TLDR
The results suggest that lordosis facilitated by free E2 is dependent on priming dose of EB, and both ERs and PRs are involved in this action of E2.
Protein kinase inhibitors infused intraventricularly or into the ventromedial hypothalamus block short latency facilitation of lordosis by oestradiol
TLDR
The hypothesis that activation of several protein kinase pathways is involved in the facilitation of lordosis by E2 in EB‐primed rats is supported, and the ventromedial hypothalamus (VMH) is determined as one of the neural sites at which those intracellular pathways participate in lordosis behaviour induced by E 2.
Temporal and Concentration‐Dependent Effects of Oestradiol on Neural Pathways Mediating Sexual Receptivity
TLDR
It is demonstrated that underlying this inhibition is oestradiol acting in the arcuate nucleus to induce β‐endorphin release, which inhibits the medial preoptic nucleus through a μ‐opioid receptor mechanism.
Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat
TLDR
The rodent model of increased sexually-motivated behaviors in which the co-administration of METH and the ovarian hormones, estradiol and progesterone, intensify the incentive properties of a sexual stimulus and increases measures of sexually-Motivated behavior in the presence of an androgen-specific cue is discussed.
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TLDR
The hypothesis that the MAPK pathway is involved in lordosis regulation by P and some of its ring A-reduced metabolites as well as by the second messenger, cGMP, is supported.
Non-ligand activation of estrous behavior in rodents: cross-talk at the progesterone receptor.
TLDR
Molecular processes resulting from second messenger signaling pathways and those from the progesterone-RP interaction synergize to elicit a full behavioral response.
Participation of growth factor signal transduction pathways in estradiol facilitation of female reproductive behavior.
TLDR
The data suggest that activation of both PI3K and MAPK by E(2) and IGF-I mediates hormonal facilitation of lordosis behavior.
Progesterone, but not LHRH or prostaglandin E2, induces sequential inhibition of lordosis to various lordogenic agents.
TLDR
Results suggest that SI is triggered only by agents that bind to the PR and that it decreases the responsiveness of rats not only to P but also to other lordogenic agents (experiment II).
Mechanisms of Ovarian Steroid Regulation of Norepinephrine Receptor-Mediated Signal Transduction in the Hypothalamus: Implications for Female Reproductive Physiology
TLDR
It is proposed that this hormone-dependent remodeling of hypothalamic responses to NE maximizes reproductive success by coordinating the timing of the preovulatory release of gonadotropins with the period of behavioral receptivity in female rodents.
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