Src kinase signaling mediates estrous behavior induced by 5β-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats

@article{LimaHernndez2012SrcKS,
  title={Src kinase signaling mediates estrous behavior induced by 5$\beta$-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats},
  author={Francisco Javier Lima-Hern{\'a}ndez and Carlos Beyer and Porfirio G{\'o}mora-Arrati and Marcos Garc{\'i}a-Ju{\'a}rez and Jos{\'e} L. Encarnaci{\'o}n-S{\'a}nchez and Anne M. Etgen and Oscar Gonz{\'a}lez‐Flores},
  journal={Hormones and Behavior},
  year={2012},
  volume={62},
  pages={579-584}
}
The progesterone receptor (PR) is a dual function protein that acts in the nucleus as a transcriptional factor and at the cytoplasm as a scaffold for the Src-MAPK signaling pathway. Several agents lacking affinity for the PR, such as 5β-reduced progestins, GnRH or prostaglandin E(2) (PGE(2)) facilitate estrous behavior in ovariectomized (ovx), estrogen-primed rats yet their action is blocked by the antiprogestin RU486. We hypothesize that these agents act by using the PR-Src-mitogen activated… 
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11 Citations

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Estrogen receptors regulate the estrous behavior induced by progestins, peptides, and prostaglandin E2
TLDR
Results suggest that activation of classical ERs participates in the triggering effects on estrous behavior induced by agents with different chemical structures that do not bind directly to ERs.
Lordosis facilitated by GPER-1 receptor activation involves GnRH-1, progestin and estrogen receptors in estrogen-primed rats
TLDR
The results suggest that GnRH release activates both estrogen and progestin receptors and that this activation is important in the chain of events leading to the display of lordosis behavior in response to activation of GPER‐1 in estrogen‐primed rats.
Sexual receptivity facilitated by unesterified estradiol: Dependence on estrogen and progestin receptors and priming dose of estradiol benzoate.
TLDR
The results suggest that lordosis facilitated by free E2 is dependent on priming dose of EB, and both ERs and PRs are involved in this action of E2.
Estrogen receptor α and β are involved in the activation of lordosis behavior in estradiol-primed rats
TLDR
The results suggest that both forms of ER are involved in the short-latency facilitation of lordosis behavior in E2-primed rats.
Lordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathways
TLDR
It is confirmed that multiple intracellular pathways participate in the expression of lordosis behavior in estrogen-primed rats elicited by leptin, and both the quotient and the lordosis score induced by leptin were significantly decreased.
Oxytocin induces lordosis behavior in female rats through the prostaglandin E2/GnRH signaling system
TLDR
Data indicate that the OT/PGE2/GnRH pathway is involved in the expression of OT-induced lordosis behavior, an effect that may be occurring directly in hypothalamic astrocytes.
Protein kinase inhibitors infused intraventricularly or into the ventromedial hypothalamus block short latency facilitation of lordosis by oestradiol
TLDR
The hypothesis that activation of several protein kinase pathways is involved in the facilitation of lordosis by E2 in EB‐primed rats is supported, and the ventromedial hypothalamus (VMH) is determined as one of the neural sites at which those intracellular pathways participate in lordosis behaviour induced by E 2.
Temporal and Concentration‐Dependent Effects of Oestradiol on Neural Pathways Mediating Sexual Receptivity
TLDR
It is demonstrated that underlying this inhibition is oestradiol acting in the arcuate nucleus to induce β‐endorphin release, which inhibits the medial preoptic nucleus through a μ‐opioid receptor mechanism.
Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat
TLDR
The rodent model of increased sexually-motivated behaviors in which the co-administration of METH and the ovarian hormones, estradiol and progesterone, intensify the incentive properties of a sexual stimulus and increases measures of sexually-Motivated behavior in the presence of an androgen-specific cue is discussed.
1.02 – Female Sexual Behavior in Rodents, Lagomorphs, and Goats
TLDR
The present chapter describes molecular, cellular, physiological, and behavioral aspects that are important for the expression of female sexual behavior in lagomorphs and goats, in addition to rodents.
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References

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TLDR
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