Src kinase signaling mediates estrous behavior induced by 5β-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats

@article{LimaHernndez2012SrcKS,
  title={Src kinase signaling mediates estrous behavior induced by 5$\beta$-reduced progestins, GnRH, prostaglandin E2 and vaginocervical stimulation in estrogen-primed rats},
  author={Francisco Javier Lima-Hern{\'a}ndez and Carlos Beyer and Porfirio G{\'o}mora-Arrati and Marcos Garc{\'i}a-Ju{\'a}rez and Jos{\'e} L. Encarnaci{\'o}n-S{\'a}nchez and Anne M. Etgen and Oscar Gonz{\'a}lez‐Flores},
  journal={Hormones and Behavior},
  year={2012},
  volume={62},
  pages={579-584}
}
The progesterone receptor (PR) is a dual function protein that acts in the nucleus as a transcriptional factor and at the cytoplasm as a scaffold for the Src-MAPK signaling pathway. Several agents lacking affinity for the PR, such as 5β-reduced progestins, GnRH or prostaglandin E(2) (PGE(2)) facilitate estrous behavior in ovariectomized (ovx), estrogen-primed rats yet their action is blocked by the antiprogestin RU486. We hypothesize that these agents act by using the PR-Src-mitogen activated… 
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