Src kinase regulates metalloproteinase-9 secretion induced by type IV collagen in MCF-7 human breast cancer cells.

@article{CortsReynosa2008SrcKR,
  title={Src kinase regulates metalloproteinase-9 secretion induced by type IV collagen in MCF-7 human breast cancer cells.},
  author={Pedro Cort{\'e}s-Reynosa and Teresa Jim{\'e}nez Robledo and Marina Mac{\'i}as-Silva and S. Vincent Wu and Eduardo Perez Salazar},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2008},
  volume={27 3},
  pages={
          220-31
        }
}
Matrix metalloproteinases (MMPs) are a family of endopeptidases that collectively are capable to degrading all components of the extracellular matrix (ECM) and they have been implicated in several aspects of tumor progression, such as invasion through basement membrane (BM) and insterstitial matrices, angiogenesis and tumor cell growth. In particular, MMP-2 and MMP-9 have been associated with the ability of tumor cells to metastasize due to their capacity to degrade type IV collagen (Col-IV… CONTINUE READING

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