Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

@article{Wallez2007SrcKP,
  title={Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site},
  author={Yann Wallez and Francine Cand and Francisco H. Cruzalegui and Christer Wernstedt and Serhiy Souchelnytskyi and Isabelle Vilgrain and Philippe Huber},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={1067-1077}
}
Src-family tyrosine kinases are regulatory proteins that play a pivotal role in the disorganization of cadherin-dependent cell–cell contacts. We previously showed that Src was associated with vascular endothelial (VE)-cadherin and that tyrosine phosphorylation level of VE-cadherin was dramatically increased in angiogenic tissues as compared to quiescent tissues. Here, we examined whether VE-cadherin was a direct substrate for Src in vascular endothelial growth factor (VEGF)-induced VE-cadherin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

Recent insights into endothelial control of leukocyte extravasation

Cellular and Molecular Life Sciences • 2016
View 14 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin.

Arteriosclerosis, thrombosis, and vascular biology • 1995
View 4 Excerpts
Highly Influenced

Angiogenesis: the VE-cadherin switch.

Trends in cardiovascular medicine • 2006
View 1 Excerpt

systems

M Potter, S Barbero, DA Cheresh
2005
View 2 Excerpts

Similar Papers

Loading similar papers…