Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia

@inproceedings{Banerjee2015SrcKA,
  title={Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia},
  author={Anamika Banerjee and Hoau-Yan Wang and Karin E. Borgmann-Winter and Mathew L Macdonald and Hagop Kaprielian and Andres Stucky and Jessica Kvasic and Chijioke N Egbujo and Rabindranath Ray and Konrad Talbot and Scott E Hemby and Steven J. Siegel and Steven E Arnold and Patrick Sleiman and Xiao Chang and Hakon Hakonarson and Raquel E. Gur and C G Hahn},
  booktitle={Molecular Psychiatry},
  year={2015}
}
Numerous investigations support decreased glutamatergic signaling as a pathogenic mechanism of schizophrenia, yet the molecular underpinnings for such dysregulation are largely unknown. In the post-mortem dorsolateral prefrontal cortex (DLPFC), we found striking decreases in tyrosine phosphorylation of N-methyl-D aspartate (NMDA) receptor subunit 2 (GluN2) that is critical for neuroplasticity. The decreased GluN2 activity in schizophrenia may not be because of downregulation of NMDA receptors… CONTINUE READING
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