Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells.

@article{Kannan2006SrcKL,
  title={Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells.},
  author={Shibichakravarthy Kannan and Aaron Audet and Jessica L Knittel and Saman Mullegama and George F. Gao and Min Wu},
  journal={European journal of immunology},
  year={2006},
  volume={36 7},
  pages={1739-52}
}
Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis. However, the role of Lyn in infectious diseases is not clear. Here, we demonstrate that Lyn activation by phosphorylation significantly impacted invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa (PA), a common opportunistic lung pathogen affecting individuals with deficient lung… CONTINUE READING
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