Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

@article{Selbach2002SrcIT,
  title={Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.},
  author={Matthias Selbach and Stefan Moese and Christof R. Hauck and Thomas F. Meyer and Steffen Backert},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 9},
  pages={6775-8}
}
The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes phosphorylated on tyrosine residues and initiates cytoskeletal rearrangements. We demonstrate here that Src-like protein-tyrosine kinases mediate CagA phosphorylation in vitro and in vivo. First, the Src-specific tyrosine kinase inhibitor PP2 specifically blocks CagA phosphorylation and cytoskeletal rearrangements thereby… CONTINUE READING
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Infect. Immun. 70, in press by gest on Sptem er 16

  • M. Selbach, S. Moese, T. F. Meyer, S. Backert
  • 2002
1 Excerpt

hp://w w w .jb.org/ D

  • M. Tian, G. S. Martin
  • Mol. Biol. Cell 8,
  • 1997
1 Excerpt

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