Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.

@article{Vigneron2005SrcIA,
  title={Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.},
  author={Arnaud Vigneron and Igor B. Roninson and Erick Gamelin and Olivier Coqueret},
  journal={Cancer research},
  year={2005},
  volume={65 19},
  pages={8927-35}
}
DNA-damaging drugs stop tumor cell proliferation by inducing apoptosis, necrosis, or senescence. Cyclin-dependent kinase inhibitor p21waf1 is an important regulator of these responses, promoting senescence and preventing aberrant mitosis that leads to cell death. Because tumors expressing oncogenic tyrosine kinases are relatively resistant to DNA-damaging agents, the effects of Src on cellular responses to anticancer drug Adriamycin were investigated. Src expression increased drug survival in… CONTINUE READING
Highly Cited
This paper has 484 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

484 Citations

0100200'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 484 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 4 Excerpts
Highly Influenced

Chemotherapy response and resistance.

Current opinion in genetics & development • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…