Src homology 2 domain-containing inositol 5' phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils.

@article{Vonakis2001SrcH2,
  title={Src homology 2 domain-containing inositol 5' phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils.},
  author={Becky Marie Vonakis and Simon Gibbons and Rebecca Sora and Jacqueline M. Langdon and Susan M. Macdonald},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 5},
  pages={
          822-31
        }
}
BACKGROUND The human recombinant histamine-releasing factor (HrHRF) acts as a complete stimulus for histamine release and IL-4 secretion from a subpopulation of highly allergic donor basophils, termed IgE(+) basophils. Additionally, IgE(+) basophils release histamine to other secretogues, IL-3, and deuterium oxide. We hypothesized that IgE(+) basophils were hyperreleasable. OBJECTIVE Deficiencies in early signal transduction events associated with Fc(epsilon)RI lead to a nonreleasable… CONTINUE READING
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