Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.

@article{Yogo2006SrcH2,
  title={Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.},
  author={Keiichiro Yogo and Megumi Mizutamari and Kazuta Mishima and Hiromi Takenouchi and Norihiro Ishida-Kitagawa and Takehiko Sasaki and Tatsuo Takeya},
  journal={Endocrinology},
  year={2006},
  volume={147 7},
  pages={3307-17}
}
c-Src plays an important role in bone resorption by osteoclasts. Here, we show using wild-type and ship(-/-) osteoclasts that Src homology 2 (SH2)-containing 5'-inositol phosphatase (SHIP) appeared to negatively regulate bone resorption activated by c-Src. SHIP was found to localize to podosomes under the influence of c-Src, and the presence of either the amino-terminal region comprising the SH2 domain or the carboxyl-terminal region was sufficient for its localization. Although SHIP lacking a… CONTINUE READING

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