Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

@article{Miyatake1998SrcFT,
  title={Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).},
  author={Shoichiro Miyatake and Chiaki Nakaseko and Hisashi Umemori and Tadashi Yamamoto and Takashi K. Saito},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={249 2},
  pages={444-8}
}
CTLA-4 (CD152) transduces inhibitory signals for T cell activation. Phosphorylation and dephosphorylation of tyrosine residue (Y)-165 in the cytoplasmic region of CTLA-4 play an important role in the signal transduction and in the cell surface. While signaling molecules such as SHP-2 and the p85 subunit of PI3 kinase associate with this tyrosine residue through SH2 domains upon phosphorylation, the adapter complex AP-2 interacts with the same tyrosine when dephosphorylated, leading to clathrin… CONTINUE READING
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