Src family kinases regulate renal epithelial dedifferentiation through activation of EGFR/PI3K signaling.

@article{Zhuang2012SrcFK,
  title={Src family kinases regulate renal epithelial dedifferentiation through activation of EGFR/PI3K signaling.},
  author={Shougang Zhuang and Meili Duan and Yan Yan},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 5},
  pages={2138-44}
}
Dedifferentiation, a process by which differentiated cells become mesenchymal-like proliferating cells, is the first step in renal epithelium repair and occurs in vivo after acute kidney injury and in vitro in primary culture. However, the underlying mechanism remains poorly understood. In this report, we studied the signaling events that mediate dedifferentiation of proximal renal tubular cells (RPTC) in primary culture. RPTC dedifferentiation characterized by increased expression of vimentin… CONTINUE READING

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