Src family kinases and their role in hematological malignancies.

@article{Ku2015SrcFK,
  title={Src family kinases and their role in hematological malignancies.},
  author={Matthew Ku and Meaghan Wall and Ruth N MacKinnon and Carl R Walkley and Louise E Purton and Constantine Si Lun Tam and David J. Izon and L. J. Campbell and Heung-Chin Cheng and Harshal H Nandurkar},
  journal={Leukemia & lymphoma},
  year={2015},
  volume={56 3},
  pages={
          577-86
        }
}
The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoiesis and leukemogenesis. The derangement of their expression or activation has been demonstrated to contribute to hematological malignancies. This review first examines the mechanisms of SFK overexpression and hyperactivation, emphasizing the dysregulation of the upstream modulators. Subsequently, the role of SFK up-regulation in the initiation, progression and… CONTINUE READING
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