Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530

@article{Chang2008SrcFK,
  title={Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530},
  author={Y-M Chang and Lina Bai and S Liu and Joy Y. Yang and H-J Kung and Christopher P. Evans},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={6365-6375}
}
Prostate cancer is the most frequently diagnosed cancer in American men. We have previously demonstrated that Src mediates androgen-independent proliferation in prostate cancer. We sought to investigate the Src-mediated oncogenic pathways and tumor biology using AZD0530, a novel Src family kinase/Abl dual-kinase inhibitor that is entering phase II clinical trials. We show that while both Src and Abl are expressed in all prostate cancer cell lines, Src but not Abl is activated in the prostate… CONTINUE READING
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