Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173

@article{Kong2011SrcFK,
  title={Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173},
  author={Lu Kong and Zhihong Deng and Haiying Shen and Yuxiang Zhang},
  journal={Molecular and Cellular Biochemistry},
  year={2011},
  volume={348},
  pages={11-19}
}
Tyrosine (Y) kinases inhibitors have been approved for targeted treatment of cancer. However, their clinical use is limited to some cancers and the mechanism of their action remains unclear. Previous study has indicated that PP2, a selective inhibitor of the Src family of non-receptor tyrosine kinases (nRTK), efficiently repressed cervical cancer growth in vitro and in vivo. In this regard, our aims are to explore the mechanism of PP2 on cervical cancer cell growth inhibition by investigating… 

Bosutinib Acts as a Tumor Inhibitor via Downregulating Src/NF‐κB/Survivin Expression in HeLa Cells

Bosutinib, as a potent dual Src/Abl inhibitor, could exert anti‐tumor effects on cervical cancer and inhibited cervical cancer cells proliferation and colony formation ability in a dose‐dependent manner, and also induced apoptosis.

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TQ induced apoptosis in HCT116 cells by blocking STAT3 signaling via inhibition of JAK2- and Src-mediated phosphorylation of EGFR tyrosine kinase.

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It is demonstrated that EGF-induced, calpain-mediated proteolysis contributes to the rapid destruction of cyclin G2 and that the PEST domain is critical for EGF/calpain actions.

Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein

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SMAD4-independent activation of TGF-β signaling by MUC1 in a human pancreatic cancer cell line

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