Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

@inproceedings{Pal2014SrcdependentIO,
  title={Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy},
  author={Rituraj Pal and Michela Sara Palmieri and James Anthony Loehr and Shumin Li and Reem Abo-Zahrah and Tanner O. Monroe and Poulami Basu Thakur and Marco Sardiello and George G. Rodney},
  booktitle={Nature communications},
  year={2014}
}
Duchenne muscular dystrophy (DMD) is a fatal degenerative muscle disease resulting from mutations in the dystrophin gene. Increased oxidative stress and altered Ca(2+) homeostasis are hallmarks of dystrophic muscle. While impaired autophagy has recently been implicated in the disease process, the mechanisms underlying the impairment have not been elucidated. Here we show that nicotinamide adenine dinucleotide phosphatase (Nox2)-induced oxidative stress impairs both autophagy and lysosome… CONTINUE READING
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