Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells.

@article{Degryse1999SrcdependenceAP,
  title={Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells.},
  author={Bernard Degryse and Massimo Resnati and Shafaat Ahmed Rabbani and Alessandra Villa and Francesca Fazioli and Francesco Blasi},
  journal={Blood},
  year={1999},
  volume={94 2},
  pages={
          649-62
        }
}
The catalytically inactive precursor of urokinase-type plasminogen activator (pro-u-PA) induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]). A soluble form of u-PAR activated by chymotrypsin cleavage as well as a peptide located between domain 1 and 2 of u-PAR reproduced the effect of pro-u-PA on cell migration. The chemotactic pro-u-PA effect correlates with a dramatic reorganization of actin… CONTINUE READING

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