Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells

@article{Huang2013SrcCT,
  title={Src contributes to IL6-induced vascular endothelial growth factor-C expression in lymphatic endothelial cells},
  author={Y Huang and H. Y. David Yang and Ya-Fen Hsu and Pei-Ting Chiu and George Ou and Ming-Jen Hsu},
  journal={Angiogenesis},
  year={2013},
  volume={17},
  pages={407-418}
}
Formation of lymphatic capillaries by lymphatic endothelial cells (LECs) occurs both in normal tissues as well as in pathological processes including tumor metastasis. Interleukin-6 (IL-6), a potent pro-inflammatory cytokine, has been shown to be highly elevated in various cancers. IL-6 has also been shown to increase tumor lymphangiogenesis through vascular endothelial growth factor-C (VEGF-C) induction in tumor cells. Although lymphangiogenesis is associated with lymph node metastasis and… CONTINUE READING
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