Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteries.

@article{Rice2002SrcAI,
  title={Src autophosphorylation is an early event in pressure-mediated signaling pathways in isolated resistance arteries.},
  author={Darian C. Rice and Anca D Dobrian and Suzanne D. Schriver and Russell L. Prewitt},
  journal={Hypertension},
  year={2002},
  volume={39 2 Pt 2},
  pages={502-7}
}
Elevated blood pressure is associated with varying degrees of arterial growth and remodeling. The mechanisms by which mechanical stress is converted into cellular alteration have yet to be fully elucidated. Our laboratory has demonstrated that Src tyrosine kinases and the extracellular signal-regulated kinase subtype of the mitogen-activated protein kinase family mediate pressure-induced c-fos expression in rat mesenteric arteries. Others have reported involvement of integrin and growth factor… CONTINUE READING