Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells.

@article{Park1995SrcAI,
  title={Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells.},
  author={J H Park and Christine A. Cartwright},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 5},
  pages={2374-82}
}
Src and Yes protein-tyrosine kinase activities are elevated in malignant and premalignant tumors of the colon. To determine whether Src activity is elevated throughout the human colon carcinoma cell cycle as it is in polyomavirus middle T antigen- or F527 Src-transformed cells, and whether Yes activity, which is lower than that of Src in the carcinoma cells, is regulated differently, we measured their activities in cycling cells. We observed that the activities of both kinases were higher… CONTINUE READING