Src activation by β-adrenoreceptors is a key switch for tumor metastasis

  title={Src activation by β-adrenoreceptors is a key switch for tumor metastasis},
  author={Guillermo N. Armaiz-Pena and Julie K. Allen and Anthony C. Cruz and Rebecca L. Stone and Alpa M Nick and Yvonne Gail Lin and Liz Y. Han and Lingegowda Selanere Mangala and Gabriel J. Villares and Pablo E. Vivas-Mej{\'i}a and Cristian Rodriguez-Aquayo and Archana Sidalaghatta Nagaraja and Kshipra M. Gharpure and Zheng Wu and Robert D. English and Kizhake V Soman and Mian M. K. Shazhad and Maya Zigler and Michael T. Deavers and Alexander Zien and Theodoros G. Soldatos and David B. Jackson and John E Wiktorowicz and Madeline Torres-Lugo and Tom Young and Koen de Geest and Gary E. Gallick and Menashe M Bar-Eli and Gabriel L{\'o}pez-Berestein and Steve W. Cole and Gustavo E. L{\'o}pez and Susan K Lutgendorf and Anil Sood},
  booktitle={Nature communications},
Noradrenaline can modulate multiple cellular functions important for cancer progression; however, how this single extracellular signal regulates such a broad array of cellular processes is unknown. Here we identify Src as a key regulator of phosphoproteomic signalling networks activated in response to beta-adrenergic signalling in cancer cells. These results also identify a new mechanism of Src phosphorylation that mediates beta-adrenergic/PKA regulation of downstream networks, thereby… CONTINUE READING
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Src continues aging: current and future clinical directions.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007

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