Src-Induced Disintegration of Adherens Junctions of Madin-Darby Canine Kidney Cells Is Dependent on Endocytosis of Cadherin and Antagonized by Tiam-1

Abstract

The effects of Src tyrosine kinase activation in subconfluent temperature sensitive (ts)–Src-transformed Madin-Darby canine kidney (MDCK) cells were analyzed by shifting them from nonpermissive (40.5° C) to permissive (35° C) temperature. Already, in 15 minutes, adherens junction components were released from the lateral walls and accumulated to basal… (More)
DOI: 10.1097/01.LAB.0000107009.75152.03

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