Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy

@inproceedings{Tan2015SrcSTAT3dependentHO,
  title={Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy},
  author={Qixing Tan and Hongli Wang and Yongliang Hu and Meiru Hu and Xiaoguang Li and Aodengqimuge and Yuan-fang Ma and Changyuan Wei and Lun Song},
  booktitle={Cancer science},
  year={2015}
}
Chemotherapeutic resistance in breast cancer, whether acquired or intrinsic, remains a major clinical obstacle. Thus, increasing tumor cell sensitivity to chemotherapeutic agents will be helpful in improving the clinical management of breast cancer. In the present study, we found an induction of HO-1 expression in doxorubicin (DOX)-treated MDA-MB-231 human breast adenocarcinoma cells, which showed insensitivity to DOX treatment. Knockdown HO-1 expression dramatically upregulated the incidence… CONTINUE READING
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