Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila.

@article{Bogdan2004Sra1IW,
  title={Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila.},
  author={Sven Bogdan and Oliver Grewe and Mareike Strunk and Alexandra M. Mertens and Christian Kl{\"a}mbt},
  journal={Development},
  year={2004},
  volume={131 16},
  pages={3981-9}
}
Regulation of growth cone and cell motility involves the coordinated control of F-actin dynamics. An important regulator of F-actin formation is the Arp2/3 complex, which in turn is activated by Wasp and Wave. A complex comprising Kette/Nap1, Sra-1/Pir121/CYFIP, Abi and HSPC300 modulates the activity of Wave and Wasp. We present the characterization of Drosophila Sra-1 (specifically Rac1-associated protein 1). sra-1 and kette are spatially and temporally co-expressed, and both encoded proteins… CONTINUE READING