Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis

@article{Norvell2005SquidIR,
  title={Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis},
  author={Amanda Norvell and Alain Debec and Daniel Finch and Lisa Gibson and Brandi Thoma},
  journal={Development Genes and Evolution},
  year={2005},
  volume={215},
  pages={340-349}
}
The nuclear–cytoplasmic shuttling heterogeneous nuclear RNA-binding protein (hnRNP) Squid (Sqd) is required during Drosophila melanogaster oogenesis, where it plays a critical role in the regulation of the TGFα-like molecule Gurken (Grk). Three Sqd isoforms have been described, SqdA, S and B, and two of these, SqdA and SqdS, differentially function in grk mRNA nuclear export, cytoplasmic transport and translational control during oogenesis. Here, we report that Sqd is also required for the… CONTINUE READING