Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.

@article{Clouse2008SquidCA,
  title={Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.},
  author={K. Nicole Clouse and Scott B Ferguson and Trudi Sch{\"u}pbach},
  journal={Developmental biology},
  year={2008},
  volume={313 2},
  pages={713-24}
}
During Drosophila melanogaster oogenesis, the proper localization of gurken (grk) mRNA and protein is required for the establishment of the dorsal-ventral axis of the egg and future embryo. Squid (Sqd) is an RNA-binding protein that is required for the correct localization and translational regulation of the grk message. We show that Cup and polyA-binding protein (PABP) interact physically with Sqd and with each other in ovaries. We show that cup mutants lay dorsalized eggs, enhance… CONTINUE READING

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