Squeezing Axons Out of the Gray Matter A Role for Slit and Semaphorin Proteins from Midline and Ventral Spinal Cord

@article{Zou2000SqueezingAO,
  title={Squeezing Axons Out of the Gray Matter A Role for Slit and Semaphorin Proteins from Midline and Ventral Spinal Cord},
  author={Yimin Zou and Esther T Stoeckli and Hang Chen and Marc Tessier-Lavigne},
  journal={Cell},
  year={2000},
  volume={102},
  pages={363-375}
}
Commissural axons cross the nervous system midline and then turn to grow alongside it, neither recrossing nor projecting back into ventral regions. In Drosophila, the midline repellent Slit prevents recrossing: axons cross once because they are initially unresponsive to Slit, becoming responsive only upon crossing. We show that commissural axons in mammals similarly acquire responsiveness to a midline repellent activity upon crossing. Remarkably, they also become responsive to a repellent… CONTINUE READING