Squaraines as fluoro-chromogenic probes for thiol-containing compounds and their application to the detection of biorelevant thiols.

@article{RosLis2004SquarainesAF,
  title={Squaraines as fluoro-chromogenic probes for thiol-containing compounds and their application to the detection of biorelevant thiols.},
  author={Jose V. Ros-Lis and Beatriz Garcia and Diego Medrano Jim{\'e}nez and Ram{\'o}n Mart{\'i}nez-M{\'a}{\~n}ez and F{\'e}lix Sancen{\'o}n and Juan Soto and Fernando Gonzalvo and M Carmen Valldecabres},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 13},
  pages={
          4064-5
        }
}
A highly selective colorimetric chemodosimeter for thiol-containing compounds in aqueous solutions is reported. The design protocol makes use of a highly specific reaction between thiols and the electrophilic four-membered ring of highly colored, fluorescent squaraine backbones. At neutral pH selective decoloration and total emission quenching was found due to the rupture of the highly delocalized squaraine framework upon selective nucleophilic addition of thiol-containing derivatives. The… CONTINUE READING
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