Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types

@inproceedings{Schwaederl2015SquamousnessNS,
  title={Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types},
  author={Maria C Schwaederl{\'e} and Sheryl K Elkin and Brett N. Tomson and Jennifer Levin Carter and Razelle Kurzrock},
  booktitle={Cell cycle},
  year={2015}
}
In order to gain a better understanding of the underlying biology of squamous cell carcinoma (SCC), we tested the hypothesis that SCC originating from different organs may possess common molecular alterations. SCC samples (N = 361) were examined using clinical-grade targeted next-generation sequencing (NGS). The most frequent SCC tumor types were head and neck, lung, cutaneous, gastrointestinal and gynecologic cancers. The most common gene alterations were TP53 (64.5% of patients), PIK3CA (28.5… CONTINUE READING
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