Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy.

@article{Drilon2012SquamouscellCO,
  title={Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy.},
  author={Alexander E Drilon and Natasha Rekhtman and Marc Ladanyi and Paul A. Paik},
  journal={The Lancet. Oncology},
  year={2012},
  volume={13 10},
  pages={e418-26}
}
Squamous-cell carcinomas of the lung (SQCLCs) are defined by unique clinicopathological and molecular characteristics that have evolved substantially over time. Historically, these neoplasms were the most common subtype of non-small-cell lung cancers and were regarded as central tumours with high molecular complexity without targetable genetic abnormalities. Today, the incidence of SQCLCs is surpassed by adenocarcinomas of the lung with a shift towards peripheral squamous tumours. Differential… CONTINUE READING
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