Squamous cell carcinoma of the oropharynx

  title={Squamous cell carcinoma of the oropharynx},
  author={James T. Parsons and William M. Mendenhall and Scott P. Stringer and Robert J. Amdur and Russell W. Hinerman and Douglas Villaret and Giselle J Moore-Higgs and Bruce D. Greene and Tod W. Speer and Nicholas J. Cassisi and Rodney R. Million},
The treatment of patients with squamous cell carcinoma (SCC) of the oropharynx remains controversial. No randomized trial has addressed adequately the question of whether surgery (S), radiation therapy (RT), or combined treatment is most effective. 

Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx

This study evaluates the oncologic outcome with regard to survival and locoregional tumor control in a cohort of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated according to a

Oncologic outcomes of surgically treated early‐stage oropharyngeal squamous cell carcinoma

The purpose of this study was to characterize oncologic outcomes in early and intermediate oropharyngeal squamous cell carcinoma (SCC) after surgery.

Locally Advanced Tonsillar Squamous Cell Carcinoma: Treatment Approach Revisited

The treatment policy for locally advanced stage III and IV squamous cell carcinoma of the tonsil at the Princess Alexandra Hospital Head and Neck Unit, Brisbane, Australia was reviewed.

Oncologic outcomes of human papillomavirus–associated oropharynx carcinoma treated with surgery alone: A 12‐institution study of 344 patients

The oncologic outcomes of surgery alone for patients with American Joint Committee on Cancer 7th edition (AJCC 7th) pN2a and pN2b human papillomavirus–associated oropharynx squamous cell carcinoma

Advanced‐staged tonsillar squamous carcinoma: Organ preservation versus surgical management of the primary site

Our aim was to review our experience in the management of advanced tonsillar squamous cell carcinoma (SCC) and to compare treatment outcomes between patients treated with and without surgery to the

A matched pair analysis of oncological outcomes in human papillomavirus‐negative oropharyngeal squamous cell carcinoma: Transoral surgery versus radiotherapy or concurrent chemoradiation

TOS+/- adjuvant was found to have oncological outcomes at par with nonsurgical modalities in stage I-III OPSCC, whereas a distinct survival advantage was noted in case of stage IV tumors.

Surgical salvage of the oropharynx after failure of organ‐sparing therapy

The purpose of this study was to evaluate the efficacy of salvage surgery for local recurrences of oropharyngeal squamous cell carcinoma (OPSCC) and identify predictors of survival.

Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation

The aim was to report the experience in conventional surgical management with particular focus on T1/T2 tumors, which may be candidates for minimally invasive techniques.

Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta‐analysis

This systematic review and meta‐analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP)

Institutional financial toxicity of failure to adhere to treatment guidelines for head and neck squamous cell carcinoma

Delays in treatment of head and neck squamous cell carcinoma (HNSCC) are known to increase disease recurrence, generating the need for additional salvage treatment, often with immunotherapy.



Surgical treatment of squamous cell carcinoma of the base of tongue

The experience with primary surgery followed by postoperative radiation therapy (XRT) to determine the impact of the treatment protocols on outcome was reviewed.

Definitive radiotherapy for T1 and T2 squamous cell carcinoma of the tonsil

To assess whether survival or local control of early squamous cell carcinoma of the tonsil has been compromised by a moderate‐dose approach, a large number of patients diagnosed with this disease have had their tonsil removed.

Carcinoma of the tonsillar region

A retrospective analysis of 171 patients with carcinoma of the tonsillar region is presented, finding the presence of nodal disease decreased survival by one half.

Radiation therapy of carcinoma of the tonsil

The results of treatment with radiation therapy of 65 cases of epidermoid carcinoma of the palatine tonsil have been reviewed and no difference in survival was noted between patients with no clinical adenopathy vs those with clinically involved movable ipsilateralAdenopathy.

Excellent functional outcome in patients with squamous cell carcinoma of the base of tongue treated with external irradiation and interstitial iodine 125 boost

Local control, functional outcome, and complications in patients with carcinoma of the base of tongue (BOT) were analyzed to assess the impact of interstitial implant boost with I‐125 seeds.

Combined surgery and postoperative radiotherapy for carcinoma of the base of tongue: Analysis of treatment outcome and prognostic value of margin status

It is the institutional policy to manage base of tongue carcinoma with combined partial glossectomy (with attempt to avoid laryngectomy if possible) with planned postoperative radiotherapy (RT), and it is reported on the institutional experience with this approach.

Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy

Background. The authors determined the patterns of treatment failure in patients treated with surgery alone or surgery combined with postoperative radiation therapy for squamous cell carcinoma of the

Local control of oropharyngeal carcinoma by irradiation alone

The accelerated hyperfractionated radiation therapy twice‐daily program was shown to achieve significantly higher 5‐year local tumor control rates and disease‐specific survival rates than the conventional once‐daily radiation therapy program (historical control).