We report the case of 37-year-old women with primary Squamous cell carcinoma of the right breast. The tumor was nodular, 13cm, with important hemorrhagic and necrotic reshaping. There was no central or peripheral cystic altering. Histologically, the tumoral cells were polyedric, dyskeratosic with intercellular junction. This rare breast entity has controversy histogenesis. The development was characterized by metastases frequency. The treatment remains no codified.