Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970

  title={Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970},
  author={Jacinthe Ch{\^e}nevert and Raja R. Seethala and Edward L. Barnes and Simion I. Chiosea},
  journal={The Laryngoscope},
From the 1950s through the 1960s, an unknown number of oropharyngeal squamous cell carcinomas (SCCs) presented with metastases to cervical lymph nodes from an unknown primary (SCCUP) and were not recognized as oropharyngeal in origin. At present, pathologic evaluation of SCCUP for human papillomavirus (HPV) improves discovery of occult oropharyngeal SCC and may partially explain increased incidence of HPV‐positive oropharyngeal SCC. 
11 Citations

Human papillomavirus-driven neck lymph node metastases from oropharyngeal or unknown primary squamous cell carcinoma

Patients with neck squamous cell carcinoma from unknown primary tumor (NSCCUP) present with lymph node metastases without evidence for a primary tumor, and patients with HPV-driven, as well as HPV-seropositive NSCCUP had significantly better overall and progression-free survival rates, and based on the observed survival benefit, HPV mRNA status assessment should be included in NS CCUP diagnosis.

Comprehensive management of HPV‐related squamous cell carcinoma of the head and neck of unknown primary

Human papillomavirus (HPV)‐related squamous cell carcinoma of unknown primary (SCCUP) is currently rising in incidence but lacks a validated management approach.

High-Risk Human Papillomavirus in Head and Neck Squamous Cell Carcinoma.

PCR-MA together with p16INK4a provided accurate assessment of HPV presence, type, and activity, and was determined to be the best approach for HPV testing in FFPE head and neck tumors.

Proton Pump Inhibitors and Histamine 2 Blockers Are Associated with Improved Overall Survival in Patients with Head and Neck Squamous Carcinoma

Routine use of antacid medications may have significant therapeutic benefit in patients with HNSCC and could lead to identification of new treatment and prevention approaches with agents that have minimal toxicities, according to this large cohort study.

Oral environment and cancer

Findings of the correlation between the oral environment and cancer are introduced and Candida, human papilloma virus and Epstein-Barr virus as well as commensal bacteria have been reported to be associated with the pathogenesis of cancer.

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

Low-dose contaminants that trigger epithelial-mesenchymal transition, for example, in these cells are of particular interest in this review and it is hoped this will lead to the collaboration between scientists who have dedicated their professional life to the study of carcinogens and those whose interests are exclusively in the arena of tissue invasion and metastasis.



Cervical lymph node metastasis: Unknown primary cancer

The dose of radiation delivered to the contralateral side of the neck prevents the subsequent appearance of nodes, and almost completely eliminates the appearance of a primary cancer in the nasopharynx and oropharynx.

Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin.

For patients with metastatic HNSCC, detection of HPV-16 is a reliable way to establish origin from the oropharynx, either directly by ISH or indirectly by immunohistochemistry for p16 overexpression.

Basaloid Squamous Cell Carcinoma of the Head and Neck is a Mixed Variant That Can be Further Resolved by HPV Status

HPV16-positivity in squamous cell carcinomas of the head and neck is now recognized as a powerful indicator of improved patient survival, and HPV16 detection thus permits resolution of a less aggressive component within a high-grade subtype of head andneck carcinoma.

Surgical treatment of squamous cell carcinoma of the tonsil

It is suggested that surgery offers a good chance of eradicating operable tonsillar carcinoma and the local recurrence rate of 19 percent in the surgical series reflects the dependence on frozen tissue examination and reflects the need to select patients suitable for surgery.

Occult tonsillar carcinoma in the unknown primary

A lower incidence of extracapsular spread and reduced recurrence rates in patients with unknown primary tumors presenting as occult tonsillar carcinoma may contribute to the improved prognosis observed in this group.

Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis.

  • P. WeinbergerZiwei Yu A. Psyrri
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
A novel classification scheme that may have value for patient stratification for clinical trials testing HPV-targeted therapies is defined, namely HPV+/p16 high (class III) in oropharyngeal squamous cell carcinoma.

Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients

HPV is significantly more common in base of tongues cancer than in mobile tongue cancer, and has a positive impact on disease‐specific survival in patients with base of tongue cancer.

Rising Incidence of Oropharyngeal Cancer and the Role of Oncogenic Human Papilloma Virus

Objectives/Hypothesis: To document the increasing incidence of oropharyngeal (OP) cancer and to provide evidence that this increase is caused by oncogenic human papilloma virus (HPV).

Changing patterns of tonsillar squamous cell carcinoma in the United States

Incidence rates of tonsillar SCC vary considerably by sex, race and time in a way that cannot be explained by changes in tonsillectomy practices alone and changes in environmental risk factors, including changes in smoking patterns and an increase in oral human papillomavirus infections.