Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970

@article{Chnevert2012SquamousCC,
  title={Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970},
  author={Jacinthe Ch{\^e}nevert and Raja R. Seethala and Edward L. Barnes and Simion I. Chiosea},
  journal={The Laryngoscope},
  year={2012},
  volume={122}
}
From the 1950s through the 1960s, an unknown number of oropharyngeal squamous cell carcinomas (SCCs) presented with metastases to cervical lymph nodes from an unknown primary (SCCUP) and were not recognized as oropharyngeal in origin. At present, pathologic evaluation of SCCUP for human papillomavirus (HPV) improves discovery of occult oropharyngeal SCC and may partially explain increased incidence of HPV‐positive oropharyngeal SCC. 
11 Citations

The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: a systematic review

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The data uncovered by this systematic review confirm that SCCUP is frequently causally associated to HPV-driven oropharyngeal squamous cell carcinomas and supports the view that HPV-status could be routinely assessed in S CCUP patients as it may lead to identifying the primary tumor and the decision to de-escalate treatment.

Human papillomavirus-driven neck lymph node metastases from oropharyngeal or unknown primary squamous cell carcinoma

Patients with neck squamous cell carcinoma from unknown primary tumor (NSCCUP) present with lymph node metastases without evidence for a primary tumor, and patients with HPV-driven, as well as HPV-seropositive NSCCUP had significantly better overall and progression-free survival rates, and based on the observed survival benefit, HPV mRNA status assessment should be included in NS CCUP diagnosis.

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PCR-MA together with p16INK4a provided accurate assessment of HPV presence, type, and activity, and was determined to be the best approach for HPV testing in FFPE head and neck tumors.

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