Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970

@article{Chnevert2012SquamousCC,
  title={Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970},
  author={Jacinthe Ch{\^e}nevert and Raja R. Seethala and Edward L. Barnes and Simion I. Chiosea},
  journal={The Laryngoscope},
  year={2012},
  volume={122}
}
From the 1950s through the 1960s, an unknown number of oropharyngeal squamous cell carcinomas (SCCs) presented with metastases to cervical lymph nodes from an unknown primary (SCCUP) and were not recognized as oropharyngeal in origin. At present, pathologic evaluation of SCCUP for human papillomavirus (HPV) improves discovery of occult oropharyngeal SCC and may partially explain increased incidence of HPV‐positive oropharyngeal SCC. 
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11 Citations

11 Citations

The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: a systematic review

  • Paolo Boscolo-RizzoL. SchroederS. RomeoMichael Pawlita
  • Medicine
    Clinical & Experimental Metastasis
  • 2015
The data uncovered by this systematic review confirm that SCCUP is frequently causally associated to HPV-driven oropharyngeal squamous cell carcinomas and supports the view that HPV-status could be routinely assessed in S CCUP patients as it may lead to identifying the primary tumor and the decision to de-escalate treatment.

Human papillomavirus-driven neck lymph node metastases from oropharyngeal or unknown primary squamous cell carcinoma

Patients with neck squamous cell carcinoma from unknown primary tumor (NSCCUP) present with lymph node metastases without evidence for a primary tumor, and patients with HPV-driven, as well as HPV-seropositive NSCCUP had significantly better overall and progression-free survival rates, and based on the observed survival benefit, HPV mRNA status assessment should be included in NS CCUP diagnosis.

Comprehensive management of HPV‐related squamous cell carcinoma of the head and neck of unknown primary

Human papillomavirus (HPV)‐related squamous cell carcinoma of unknown primary (SCCUP) is currently rising in incidence but lacks a validated management approach.

Do high-risk human papillomaviruses cause oral cavity squamous cell carcinoma?

The role of human papilloma virus and p16 in occult primary of the head and neck: a comprehensive review of the literature.

High-Risk Human Papillomavirus in Head and Neck Squamous Cell Carcinoma.

PCR-MA together with p16INK4a provided accurate assessment of HPV presence, type, and activity, and was determined to be the best approach for HPV testing in FFPE head and neck tumors.

Proton Pump Inhibitors and Histamine 2 Blockers Are Associated with Improved Overall Survival in Patients with Head and Neck Squamous Carcinoma

Routine use of antacid medications may have significant therapeutic benefit in patients with HNSCC and could lead to identification of new treatment and prevention approaches with agents that have minimal toxicities, according to this large cohort study.

Oral epithelial stem cells - implications in normal development and cancer metastasis.

Oral environment and cancer

Findings of the correlation between the oral environment and cancer are introduced and Candida, human papilloma virus and Epstein-Barr virus as well as commensal bacteria have been reported to be associated with the pathogenesis of cancer.

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

Low-dose contaminants that trigger epithelial-mesenchymal transition, for example, in these cells are of particular interest in this review and it is hoped this will lead to the collaboration between scientists who have dedicated their professional life to the study of carcinogens and those whose interests are exclusively in the arena of tissue invasion and metastasis.

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