In a review of neoplasm registry records at Kansas State University (1961 through 1971), 112 squamous cell carcinomas were reported in 38 breeds of dogs, representing 3.2% of 3,481 neoplasms recorded. Mean age of the affected dogs was 8.3 years. Metastases occurred in 7 dogs. The tumors were removed surgically for biopsy in 104 dogs, 8 of which then had recurrences and required further surgery. The oral cavity was the principal site (18%) of squamous cell carcinomas in the 112 dogs.