Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues.

@article{Caron2010SqualenoylNM,
  title={Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues.},
  author={Joachim Caron and Lakkireddy Harivardhan Reddy and Sinda Lep{\^e}tre-Mouelhi and S{\'e}verine Wack and Pascal Clayette and Christine Rogez-Kreuz and Rahima Yousfi and Patrick Couvreur and Didier Desma{\"e}le},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 9},
  pages={2761-4}
}
4-(N)-1,1',2-trisnor-squalenoyldideoxycytidine monophosphate (SQddC-MP) and 4-(N)-1,1',2-trisnor-squalenoylgemcitabine monophosphate (SQdFdC-MP) were synthesized using phosphoramidite chemistry. These amphiphilic molecules self-assembled to about hundred nanometers size nanoassemblies in aqueous medium. Nanoassemblies of SQddC-MP displayed significant anti-HIV activity whereas SQdFdC-MP nanoassemblies displayed promising anticancer activity on leukemia cells. These results suggested that… CONTINUE READING

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