Squalene synthase: structure and regulation.

  title={Squalene synthase: structure and regulation.},
  author={Terese R. Tansey and Ishaiahu Shechter},
  journal={Progress in nucleic acid research and molecular biology},
Squalene synthase (SQS) catalyzes the first reaction of the branch of the isoprenoid metabolic pathway committed specifically to sterol biosynthesis. Regulation of SQS is thought to direct proximal intermediates in the pathway into either sterol or nonsterol branches in response to changing cellular requirements. The importance of SQS in cholesterol metabolism has stimulated research on the mechanism, structure, and regulation of the enzyme. SQS produces squalene, a C30 isoprenoid, in a two… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…