Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen.

@article{Ryu2009SqualeneAA,
  title={Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen.},
  author={Akemi Ryu and Kumi Arakane and Chiharu Koide and Hiroyuki Arai and Tetsuo Nagano},
  journal={Biological & pharmaceutical bulletin},
  year={2009},
  volume={32 9},
  pages={1504-9}
}
Based on our previous finding (Biochem. Biophys. Res. Commun., 223, 578-582, 1996) of singlet oxygen generation from coproporphyrin excreted on the skin surface from Propionibacterium acnes, we hypothesized that singlet oxygen formed in this way under UV exposure would promote peroxidation of skin surface lipids. We found that squalene was oxidized efficiently by singlet oxygen derived from coproporphyrin under UV exposure, and that the rate constant of squalene peroxidation by singlet oxygen… CONTINUE READING

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