SpyRings Declassified: A Blueprint for Using Isopeptide-Mediated Cyclization to Enhance Enzyme Thermal Resilience.

Abstract

Enzymes often have marginal stability, with unfolding typically leading to irreversible denaturation. This sensitivity is a major barrier, both for de novo enzyme development and for expanding enzyme impact beyond the laboratory. Seeking an approach to enhance resilience to denaturation that could be applied to a range of different enzymes, we developed… (More)
DOI: 10.1016/bs.mie.2016.05.004

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Cite this paper

@article{Schne2016SpyRingsDA, title={SpyRings Declassified: A Blueprint for Using Isopeptide-Mediated Cyclization to Enhance Enzyme Thermal Resilience.}, author={C{\'e}drik D Sch{\"o}ne and S. P. Bennett and Mark Howarth}, journal={Methods in enzymology}, year={2016}, volume={580}, pages={149-67} }