SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis.

  title={SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis.},
  author={P. Veiga and Carmen Bulbarela-Sampieri and Sylviane Furlan and Aur{\'e}lie Maisons and Marie-Pierre Chapot-Chartier and Michael Erkelenz and Peggy Mervelet and Philippe Noirot and Dorte Frees and Oscar P. Kuipers and Jan Kok and Alexandra Gruss and Girbe Buist and Saulius Kulakauskas},
  journal={The Journal of biological chemistry},
  volume={282 27},
Endogenous peptidoglycan (PG)-hydrolyzing enzymes, the autolysins, are needed to relax the rigid PG sacculus to allow bacterial cell growth and separation. PGs of pathogens and commensal bacteria may also be degraded by hydrolases of animal origin (lysozymes), which act as antimicrobials. The genetic mechanisms regulating PG resistance to hydrolytic degradation were dissected in the Gram-positive bacterium Lactococcus lactis. We found that the ability of L. lactis to counteract PG hydrolysis… CONTINUE READING


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