Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis

@article{You2008SpxMO,
  title={Spx mediates oxidative stress regulation of the methionine sulfoxide reductases operon in Bacillus subtilis},
  author={Conghui You and Agnieszka Sekowska and Olivera Francetic and Isabelle Martin-Verstraete and Yiping Wang and Antoine Danchin},
  journal={BMC Microbiology},
  year={2008},
  volume={8},
  pages={128 - 128}
}
All aerobically grown living cells are exposed to oxidative damage by reactive oxygen species (ROS). A major damage by ROS to proteins is caused by covalent modifications of methionine residues giving methionine sulfoxide (Met-SO). Methionine sulfoxide reductases are enzymes able to regenerate methionine and restore protein function after oxidative damage. We characterized the methionine sulfoxide reductase genes msrA and msrB in Bacillus subtilis, forming an operon transcribed from a single… CONTINUE READING

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