Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma.

@article{Culpitt2005SputumMM,
  title={Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma.},
  author={Sarah V Culpitt and Duncan F. Rogers and Suzanne L. Traves and Peter J Barnes and Louise E Donnelly},
  journal={Respiratory medicine},
  year={2005},
  volume={99 6},
  pages={703-10}
}
Asthma and chronic obstructive pulmonary disease (COPD) are different conditions with contrasting airway inflammation and parenchymal disease patterns. A number of matrix metalloproteases (MMPs) are implicated in the pathophysiology of COPD and asthma. Different profiles of airway MMPs may, therefore, be expected in asthma and COPD. The present study compared MMP profiles in the airways of non-smokers, non-symptomatic cigarette smokers, and patients with COPD or asthma (n = 15 subjects per… CONTINUE READING

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Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Sputum from COPD patients had 3-fold higher levels of TIMP-1 than samples from asthmatics or controls , but was not different to smokers .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
Asthma and chronic obstructive pulmonary disease ( COPD ) are different conditions with contrasting airway inflammation and parenchymal disease patterns .
A number of matrix metalloproteases ( MMPs ) are implicated in the pathophysiology of COPD and asthma .
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