Sputum inflammatory phenotypes are not stable in children with asthma.

@article{Fleming2012SputumIP,
  title={Sputum inflammatory phenotypes are not stable in children with asthma.},
  author={Louise Fleming and Lemonia Tsartsali and Nicola Wilson and Nicolas Regamey and Andrew Bush},
  journal={Thorax},
  year={2012},
  volume={67 8},
  pages={675-81}
}
BACKGROUND Two distinct, stable inflammatory phenotypes have been described in adults with asthma: eosinophilic and non-eosinophilic. Treatment strategies based on these phenotypes have been successful. This study evaluated sputum cytology in children with asthma to classify sputum inflammatory phenotypes and to assess their stability over time. METHODS Sputum induction was performed in 51 children with severe asthma and 28 with mild to moderate asthma. Samples were classified as eosinophilic… CONTINUE READING