Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3

@inproceedings{Kato2013Spt6PT,
  title={Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3},
  author={Hiroaki Kato and Kosuke Okazaki and Tetsushi Iida and Jun-ichi Nakayama and Yota Murakami and Takeshi Urano},
  booktitle={Scientific reports},
  year={2013}
}
The tail of histone H3 is an ideal medium for storing epigenetic information because displacement of histone H3 is heavily restricted during transcription. To maintain the locus-specific modifications of histone H3, histone molecules should be retained locally at the original position through multiple rounds of transcription. Here, we found that fission yeast Spt6, a highly conserved RNA polymerase II-interacting histone H3-H4 chaperone, is essential for the maintenance of Lys-4 and Lys-9… CONTINUE READING
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