Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.

@article{Kuracha2011Spry1AS,
  title={Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation.},
  author={Murali R. Kuracha and Daniel Lee Burgess and Ed Siefker and Jake T Cooper and Jonathan D Licht and Michael L Robinson and V. Hedatale Govindarajan},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 9},
  pages={
          6887-97
        }
}
PURPOSE The studies reported here were performed to analyze the roles of Sproutys (Sprys), downstream targets and negative feedback regulators of the fibroblast growth factor (FGF) signaling pathway, in lens and corneal differentiation. METHODS Spry1 and -2 were conditionally deleted in the lens and corneal epithelial precursors using the Le-Cre transgene and floxed alleles of Spry1 and -2. Alterations in lens and corneal development were assessed by hematoxylin and eosin staining, in situ… CONTINUE READING

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