Sprouting and regeneration after pyramidotomy and blockade of the myelin-associated neurite growth inhibitors NI 35/250 in adult rats.

@article{Raineteau1999SproutingAR,
  title={Sprouting and regeneration after pyramidotomy and blockade of the myelin-associated neurite growth inhibitors NI 35/250 in adult rats.},
  author={Olivier Raineteau and W J Z'Graggen and Michaela Thallmair and Martin E. Schwab},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 4},
  pages={
          1486-90
        }
}
After a selective unilateral lesion of the corticospinal tract (CST) at the level of the brainstem (pyramidotomy) and neutralization of the myelin associated neurite growth inhibitors NI-35/250 with the monoclonal antibody (mAb) IN-1, we had previously observed a strong behavioural recovery in parallel with an enhanced structural plasticity of the lesioned as well as the unlesioned CST. The present study focuses on the regenerative response of the cut CST axons at the lesion site in these adult… CONTINUE READING
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