Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

@inproceedings{Mardakheh2009Spred2IW,
  title={Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling},
  author={Faraz K Mardakheh and Mona Yekezare and Laura M Machesky and John K. Heath},
  booktitle={The Journal of cell biology},
  year={2009}
}
The potential for modulation of growth factor signaling by endocytic trafficking of receptors is well recognized, but the underlying mechanisms are poorly understood. We examined the regulation of fibroblast growth factor (FGF) signaling by Sprouty related with EVH1 (Ena/VASP homology 1) domain (Spred), a family of signaling inhibitors with proposed tumor-suppressive functions. The inhibitory activity of Spreds has been linked to their N-terminal EVH1 domain, but the molecular mechanism is… CONTINUE READING
14 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…